TargetF15- S-adeosylmethionine syntheses(M. tuberculosis)...............................................................................Ana R., Bethany R.

Edit 1 …
Target:
S-adenosylmethionine synthetase(M. tuberculosis)

Organism:

M. tuberculosis


Prefix IDT Ordering:
MtSAMs


Forward Tail Primer in 5' to 3' orientation:

5’ TACTTCCAATCCATGGTTTCTGAAAAAGGTCGT 3’


Reverse Tail Primer in 5' to 3' orientation:

5’ TATCCACCTTTACTGTTAGATCGCACGTTTGAGAT 3’


Disease/Relevance

Tuberculosis


Type (anhydrase, reductase, phosphatase, etc.):
Synthase


E.C.

2.5.1.6 (methionine adenosyltransferase) same-same


structure:

3TDE


activity (from Brenda site)

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine


assay

Comparative protein modeling of methionine S-adenosyltransferase (MAT) enzyme from Mycobacterium tuberculosis: a potential target for antituberculosis drug discovery, shows essentiality


Essentiality

Comparative protein modeling of methionine S-adenosyltransferase (MAT) enzyme from Mycobacterium tuberculosis: a potential target for antituberculosis drug discovery, shows essentiality


Druggability
0.5


TDR Targets Link or EuPath, etc

http://tdrtargets.org/targets/view?gene_id=6457


Gene (NOT gene ontology)

Tuberculist / Rv1392


protein/clone/DNA available

substrate available?

supplier

Second Substrate

# of inhibitors

known inhibitors

Notes B

http://www.ncbi.nlm.nih.gov/pubmed/15670956


Notes D (a.a. size)

261 aa















0.5